Syk Inhibitor

Code: 574711-5MG D2-231

Biochem/physiol Actions

Reversible: yes

Product competes with ATP.

EC50 = 313 nM against FcεRI-mediated degranulation in the rat basophilic leukemia cell lin...


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€251.60 EACH
€309.47 inc. VAT

Biochem/physiol Actions

Reversible: yes

Product competes with ATP.

EC50 = 313 nM against FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3

Cell permeable: yes

General description

A cell-permeable, potent, reversible, and ATP-competitive Spleen Tyrosine Kinase (Syk) inhibitor (IC50 = 14 nM). Shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC50 = 313 nM).

A cell-permeable oxindole compound that acts as a potent, reversible, and ATP-competitive Syk inhibitor (IC50 = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC50 = 313 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett.13, 3111.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

assay≥97% (sum of two isomers, HPLC)
colordeep orange
formsolid
manufacturer/tradenameCalbiochem®
potency14 nM IC50
Quality Level100
shipped inambient
solubilityDMSO: 5 mg/mL
storage conditionprotect from light, OK to freeze
storage temp.2-8°C
Cas Number622387-85-3
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