Biochem/physiol Actions
Reversible: yes
Product competes with ATP.
EC50 = 313 nM against FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3
Cell permeable: yes
General description
A cell-permeable, potent, reversible, and ATP-competitive Spleen Tyrosine Kinase (Syk) inhibitor (IC50 = 14 nM). Shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC50 = 313 nM).
A cell-permeable oxindole compound that acts as a potent, reversible, and ATP-competitive Syk inhibitor (IC50 = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC50 = 313 nM).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Lai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett.13, 3111.
Packaging
5 mg in Glass bottle
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: